Group-24

NuMat Medtech

NuMat Medtech is focusing on 2 bioactive coatings, based on small molecules of natural origin, with potential applications in dental and orthopedic markets. The coatings developed by NuMat are trying to address the main challenges of the current commercial medical implants, including poor osteointegration and high risk of infection.


 

NM_973


Bioactive nano-surface modified with a flavonoid that shows osteogenic, osteoinductive, anti-inflammatory and anti-fibrotic properties, promoting at the same time significant reduction of bacterial colonization around implant surfaces

NM_973 is a nano-scale coating based on flavonoids, small polyphenolic molecules derived from plants with antioxidant, anti-inflammatory and antibacterial properties. They are present in the daily human diet and their intake has been related to the prevention of cancer,  and of cardiovascular and neurological diseases.

Metal surfaces coated with the flavonoid can promote both soft and hard tissue integration, which is of high interest in order to avoid peri-implantitis occurrence in dental implants, thus decreasing implant loss risks.

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Osseointegration properties

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Soft Tissue regeneration surrounding the implant

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Anti-inflammatory effect

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Reduced Bacterial colonization

Bioactive surface modified with flavonoids

Publications

Córdoba, A.; et al. (2018). Quercitrin Nanocoated Implant Surfaces Reduce Osteoclast Activity In Vitro and In Vivo. Int J Mol Sci 19(11): pii: E3319.

Córdoba, A.; et al. (2015). Flavonoid-Modified Surfaces: Multifunctional Bioactive Biomaterials with Osteopromotive, Anti-Inflammatory, and Anti-Fibrotic Potential. Advanced Healthcare Materials 4(4): 540-549

Satúe, M.; et al. (2013). Quercitrin and Taxifolin stimulate osteoblast differentiation in MC3T3-E1 cells and inhibit osteoclastogenesis in RAW 264.7 cells. Journal of Periodontology 85(7):966-74.

Gomez-Florit, M.; et al. (2016). Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria. Scientific Reports 6: 22444.

Gómez-Florit, M.; et al. (2015). Quercitrin for periodontal regeneration: effects on human gingival fibroblasts and mesenchymal stem cells. Scientific Reports 5:16593

Córdoba, A.; et al. (2015). Bioinspired quercitrin nanocoatings: A fluorescence-based method for its surface quantification, and its effect on stem cell adhesion and differentiation to the osteoblastic lineage. ACS Applied Materials & Interfaces 7 (30): 16857–16864

Gómez-Florit, M.; et al. (2014). Identification of quercitrin as potential therapeutic agent for periodontal applications. Journal of Periodontology 85(7):966-74.