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NuMat Medtech

NuMat Medtech has focused on 2 bioactive coatings, based on small molecules of natural origin, with potential applications in dental and orthopedic markets. The coatings developed by NuMat are trying to solve the main problems with current commercial osteoimplants, including poor osteointegration and high risk of infection.


 

NM_973


Bioactive surface modified with flavonoids with osteogenic, osteoinductive, anti-inflammatory, anti-fibrotic properties and significant reduction of bacteria colonization

NM_973 is a coating based on flavonoids, small polyphenolic molecules derived from plants with antioxidant, anti-inflammatory and antibacterial properties. They are present in the daily human diet and their intake has been related to the prevention of cancer, cardiovascular and neurological diseases.

Metal surfaces coated with the flavonoid can promote both soft and hard tissue integration, which is of high interest in order to avoid peri-implantitis occurrence in dental implants, thus decreasing implant loss risks.

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Osteointegrative properties

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Soft Tissue regeneration surrounding the implant

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Anti-inflammation effect

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Reduce Bacteria colonization

Bioactive surface modified with flavonoids

Publications

Córdoba, A.;et al. (2018). Quercitrin Nanocoated Implant Surfaces Reduce Osteoclast Activity In Vitro and In Vivo. Int J Mol Sci 19(11): pii: E3319.

Córdoba, A.; et al. (2015). Flavonoid-Modified Surfaces: Multifunctional Bioactive Biomaterials with Osteopromotive, Anti-Inflammatory, and Anti-Fibrotic Potential. Advanced Healthcare Materials 4(4): 540-549

Satúe, M.; et al. (2013). Quercitrin and Taxifolin stimulate osteoblast differentiation in MC3T3-E1 cells and inhibit osteoclastogenesis in RAW 264.7 cells. Journal of Periodontology 85(7):966-74.

Gomez-Florit, M.;et al. (2016). Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria. Scientific Reports 6: 22444.

Gómez-Florit, M.; et al. (2015). Quercitrin for periodontal regeneration: effects on human gingival fibroblasts and mesenchymal stem cells. Scientific Reports 5:16593

Córdoba, A.; et al. (2015). Bioinspired quercitrin nanocoatings: A fluorescence-based method for its surface quantification, and its effect on stem cell adhesion and differentiation to the osteoblastic lineage. ACS Applied Materials & Interfaces 7 (30): 16857–16864

Gómez-Florit, M.; et al. (2014). Identification of quercitrin as potential therapeutic agent for periodontal applications. Journal of Periodontology 85(7):966-74.